Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer—A pilot study

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Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer—A pilot study

The safety and efficacy of carbon-ion radiotherapy for advanced non-small cell lung cancer have not been established. We evaluated the clinical outcomes and dose-volume histogram parameters of carbon-ion radiotherapy compared with photon therapy in T2b-4N0M0 non-small cell lung cancer. Twenty-three patients were treated with carbon-ion radiotherapy between May 2011 and December 2015. Seven, 14,...

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BACKGROUND Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause acute exacerbation of ILD. This study evaluated the toxicity and efficacy of carbon ion radiotherapy (CIRT) in patients with non-small cell lung cancer (NSCLC) and ILD. METHOD...

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Current Advances in Radiotherapy for Non-Small-Cell Lung Cancer: from Conventional Radiotherapy to Carbon-Ion Radiotherapy

The prevalence of and mortality due to lung cancer have been steadily increasing worldwide. Based on differences in treatment strategies, lung cancer can be classified as non-smallcell lung cancer (NSCLC) and small-cell lung cancer (SCLC). NSCLC mainly consists of adenocarcinoma and squamous cell carcinoma, comprising about 80% of the total lung cancer cases. The treatment strategy for NSCLC is...

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Carbon-ion radiotherapy—basic and clinical studies

Radiotherapy using charged and/or high-LET particles has a long history, starting with proton beams. In vitro data clarify that RBE (Relative Biological Effectiveness) increases with LET up to approximately 150 keV/μm for carbon-12 and neon-20 ions. In vivo studies show that tumor control probabilities after single doses of gamma rays shift to higher doses when tumors were irradiated with 5-fra...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2017

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0175589